简 历
陈心春 博士
深圳大学医学部副主任兼基础医学院院长，深圳大学特聘教授
广东省组织器官区域免疫与疾病重点实验室主任
联系方式：
广东省深圳市南山区学苑大道1066号深圳大学丽湖校区A7-549，邮编518060
86-138-2367-1248
chenxinchun@szu.edu.cn, chengxinchun@163.com
教育背景:
1989年9月至1992年7月: 江西省赣南医学院临床医学专业学习
1995年9月至1998年7月: 广州中山医科大学肿瘤病毒学硕士
2001年5月至2001年10月：中国预防医学科学院病毒学研究所进修
2002年8月至2006年11月: 美国亚利桑那大学 (University of Arizona) ,
微生物与免疫学专业博士
工作经历:
1992年7月至1995年8月: 江西省新华煤矿医院内科 住院医师
1998年7月至2002年8月: 深圳市东湖医院内科 住院医师，主治医师
2006年3月至2016年7月: 深圳市第三人民医院 副主任医师，主任医师；
深圳市肝病研究所副所长，所长；医院党委委员
2016年7月— 至今 : 深圳大学特聘教授，基础医学院副院长，院长
深圳大学医学部副主任
获奖情况:
1) 金奇，高磊，陈心春，孙海兰，刘海鹰，杨枢敏，徐祖辉，沈飞，王志坚，司红艳。结合潜伏感染的流行特征、发病机制及预防干预，中华医学科技奖，二等奖，2022
2) 金奇，高磊，陆伟，白丽琼，何爱伟，蔡毅，刘自森，王大宽，孙海兰，刘立国，陈心春，张明霞，刘建民，陈天柱，张浩然。结合潜伏感染的流行和发病特征及精准干预，中华预防医学会科技奖，一等奖，2021
3) 高磊，金奇，刘建民，潘守国，张笑冰，成诗明，何爱伟，陆伟，白丽琼，陈心春，赵雁林，辛赫男，张浩然，郑建华，肖伟明。结合潜伏感染的流行特征与适宜干预技术，中国防痨协会科学技术奖，一等奖，2021
4) 陈心春，曾谷城，杨倩婷，廖明凤，张明霞，邓群益。Th17/Th22细胞在结核病中的应答特征及其调控机制，深圳市自然科学奖，一等奖，2016
5) 黄健，杨桂林，刘威龙，袁静，周伯平，陈心春。从乙肝到HBV相关肝癌的发病机制研究，深圳市自然科学奖，一等奖，2015
6) 陈心春，周伯平，肖松生，杨倩婷，张明霞，廖明凤，张洁云，朱秀云，邓群益，陈骑，张国良，陆普选，单万水。结核感染Elispot诊断试剂的研发及应用，中华预防医学会科技奖励，二等奖，2013
7) 陈心春，周伯平，张钰，张明霞，闵凡贵，杨倩婷，廖明凤，王静，张国良.结核菌感染免疫的特征和调节机制及其在临床诊断中的应用，广东省科学技术奖，二等奖，2013
8) 周伯平，陈心春，杨倩婷，张明霞，肖松生，廖明凤，胡德明，张洁云，朱秀云，何林，陈骑，邓群益，张国良，陆普选，单万水。结核感染Elispot诊断试剂的研发及应用，深圳市科技进步奖，一等奖，2012
9) 周伯平，陈心春，张明霞，余卫业，李美忠，杨倩婷，叶涛生，蔡雄茂，朱秀云，邓群益，陆普选，李国保，付向东，刘智，邓永聪。结核病CD4T细胞免疫机制研究，中华预防医学会科技奖励，二等奖，2011
10) 陈心春，吴长有，周伯平，李丽，张明霞，李美忠，廖明凤，邓群益。调节性T细胞对结核病细胞免疫的抑制作用，深圳市自然科学奖，2010
11) 乙型病毒性肝炎多价治疗性疫苗的初步研究 （深圳市科技进步二等奖，成果登记号2004298.课题第一负责人) 2005
12) 新型肝炎病毒研究（深圳市科技进步二等奖,第5完成人） 2005
13) TTV蛋白在大肠杆菌中的表达与抗-TTV酶免疫诊断试剂的研制 (深圳市科技进步奖二等奖. 证书号022020. 第3名) 2002
14) 结核分支杆菌IS6110序列的分子克隆及其在结核病基因诊断中的应用(深圳市科技进步3等奖. 证书号023059. 第1名) , 2002
专利和应用：
1) 陈心春，胡云龙，蔡毅，张惠华，杨浩。与活动性肺结核有关的miRNA标志物及其应用，2022，中国，发明专利，专利号CN202111614198.9
2) 陈心春，蔡毅，张惠华，胡云龙。与抗结核疗效评估有关的miRNA标志物及其应用，2022，中国，发明专利，专利号CN202111614140.4
3) 蔡毅，陈心春，欧阳琪。替尼泊苷在抗结核分枝杆菌药物中的应用，2022，中国，发明专利，专利号ZL201910440671.2
4) 陈心春，蔡毅，杨倩婷，周伯平。xCT抑制剂的用途，2016，中国，发明专利，专利号201410736443.7
5) 陈心春，周伯平，蔡毅，杨倩婷，张明霞，翟景南. CD263基因的用途，2014，中国，发明专利，专利号ZL201210589472.6
6) 陈心春，蔡毅，周伯平，杨倩婷，张明霞. CD157基因的用途，2013，中国，发明专利，专利号ZL201210580667.4
7) 陈心春，周伯平，张明霞，杨倩婷，蔡毅，张影。HBB基因的用途，2013，中国，发明专利，专利号ZL201210589471.1
8) 陈心春，周伯平，杨倩婷，张明霞，蔡毅，张国良。CPPED1基因的用途，2014，中国，发明专利，专利号ZL 201210591825.6
9) 陈心春，杨倩婷，周伯平，蔡毅，张明霞，汤跃强，赵桅. C1q基因及其编码蛋白的用途，2013，中国，发明专利，专利号：ZL201210589473.0
10) 陈心春，张明霞，周伯平，杨倩婷蔡毅，张影。CREB5基因的用途，2014，中国，发明专利，专利号ZL201210589452.9
11) 陈心春，周伯平，杨倩婷，张明霞。结核菌感染的酶联免疫斑点诊断试剂盒及特异性抗原提取方法，2012.10，中国，发明专利，专利ZL20081 0141800.X
12) 专利转化产品：结核特异性糖蛋白检测试剂盒（酶联免疫斑点法）粤食药监械（准）字2012第2400025号
承担课题（项目负责人）:
作为项目负责人，累计获得国家杰出青年科学基金1项，国家科技重大专项1项，国家自然科学基金重大集成项目1项，重点项目1项，面上项目4项，国家传染病专项子项目4项，以及省市项目若干。
1. 国家自然科学基金重点项目，82130066，结核菌促进巨噬细胞铁蛋白降解的机制及其在结核病发生发展中的作用，2022/01-2025/12，290万，在研，主持；
2. 深圳湾实验室开放基金，SZBL2020090501010,巨噬细胞铁代谢调控在结核病发生发展中的作用和机制，2021/01-2023/10，200万元，在研，主持；
3. 深圳市基础研究重点项目，JSYJ20200109105012589，基2020N332 新型抗耐药分枝杆菌活性分子的发现及其作用机理研究，2020/01- 2022/12，150万元，在研
4. 国家自然科学基金重大研究计划集成项目，91942315，肺组织CD8T细胞免疫学特性及其在结核病发生发展中的作用，2020/01- 2022/12，250万元，在研
5. 广东省重点实验室，2019B030301009，广东省组织器官区域免疫与疾病重点实验室，2019/01-2021/12，300万元，在研
6. 国家十三五科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”专题课题，2017ZX10201301，菌阴结核病和结核分枝杆菌潜伏感染相关生物标志物研究，2017/01-2020/12，4691.15万元，在研，
7. 国家自然科学基金面上项目，81772145，DNA甲基化在结核菌下调CD4 T细胞表面IL-6R中的作用和作用机制，2018/01-2021/12，56.0万元，在研
8. 深圳市技术攻关项目，JSGG20160427104724699，重20160392 糖尿病患者结核病精准治疗策略研究，2016/06/22-2018/06/30，350.0万元，已结题
9. 国家杰出青年科学基金，81525016，感染免疫，2016/01-2020/12，400.0万元，在研，
10. 国家自然科学基金面上项目，81273140，IL1B/TGFB/IL6/IL17A基因SNP与结核病易感性的关联分析及其作用机制研究，2013/01-2016/12，75.0万元，已结题
11. 国家十二五科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”专题分项目，2013ZX10003004-002，结核分枝杆菌感染的流行病学调查和队列研究，2013/01-2015/12，288.0万元，已结题
12. 国家十二五科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”专题分项目，2012ZX10003002-005，结核病分子标识研究，2012/01-2015/12，194.0万元，已结题
13. 国家自然科学基金面上项目，81171535，CD19＋CD5＋CD1d＋B细胞抑制Th17的作用和作用机制及其在结核病发生中的意义，2012/1-2015/12，58 万，已结题
14. 国家自然科学基金面上项目，30872258，结核分枝杆菌诱导的Th17 应答及其在人结核病发生中的作用，2009/01-2011/12，33.0万元，已结题
15. 国家十一五科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”专题子课题项目，2008ZX10003-005，结核病诊断分子标识研究，2008/1-2010/12，140.0万元，已结题
16. 国家十一五科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”专题子课题项目，2008ZX10003-012，结核病免疫保护机制研究，2008/1-2010/12，192.0万元，已结题
17. 国家自然科学基金面上项目，30671857，CD4CD25+ 天然调节性T 细胞对肺结核患者细胞免疫的调节作用及其在肺结核发病中的意义，2007/01-2009/12，29.0万元，已结题
学术兼职:
v SCI专业杂志编委 (Editor board)
《Tuberculosis 》Editor board
《Scientific Reports 》Editor board
《新发传染病电子杂志》副主编
v 专业杂志特约审稿人 (Reviewer)
American Journal of Respiratory and Critical Care Medicine
Clinical Infectious Diseases
PLoS Pathogen
Journal of Infectious Disease
Tuberculosis
Clinical Immunology
v 学术团体任职
中国防痨协会标准化委员会副主任委员
广东省免疫学会 副理事长
广东省防痨协会基础委员会 副主任委员
v 基金评审
国家传染病“十一五”“十二五”专项结核组评审专家
国家自然科学基金面上、青年、重点、杰青一审二审专家
广东省、浙江省、江苏省自然科学基金，评审专家
教育部回国人员基金评审专家
深圳市科技评审专家
发表论著 （第一/通讯作者论文58篇；共同作者论文53篇）
l 第一作者和通讯作者论文：
（# 井号标注的为共同第一作者，* 星号标注的为通讯作者/共同通讯作者；IF 为杂志影响因子；申请者以下划线标出）
1. Cai, Y.#, Wang, Y.#, Shi, C.#, Dai, Y., Li, F., Xu, Y., Zhang, P., Kong, F., Deng, G., Wen, Z., Zhou, Q., Kang, B. C., Singhal, A., Yang, Q., Feng, C. G.*, & Chen, X*. (2022). Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion. The Journal of experimental medicine, 219(3), e20211777. https://doi.org/10.1084/jem.20211777
2. Mo, S., Liu, X., Zhang, K., Wang, W., Cai, Y., Ouyang, Q., Zhu, C., Lin, D., Wan, H., Li, D., Wen, Z., & Chen, X*. (2022). Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin-dependent phagosome maturation. Journal of leukocyte biology, 111(5), 1021–1029. https://doi.org/10.1002/JLB.4A0221-119RR
3. Dai, Y., Xie, L., Wang, X., Zhang, H., Rong, H., Tu, J., & Chen, X*. (2021). Depression increases the risk of tuberculosis: Preliminary observations. The Journal of infection, 83(4), 496–522. https://doi.org/10.1016/j.jinf.2021.07.026
4. Ning, Y.#, Cai, Y.#, Dai, Y., Li, F., Mo, S., Werz, O*., & Chen, X*. (2021). Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy. Infection and immunity, 89(11), e0030621. https://doi.org/10.1128/IAI.00306-21
5. Zhu, C.#, Cai, Y.#, Mo, S., Zhu, J., Wang, W., Peng, B., Guo, J., Zhang, Z.*, & Chen, X*. (2021). NF-κB-mediated TET2-dependent TNF promoter demethylation drives Mtb-upregulation TNF expression in macrophages. Tuberculosis (Edinburgh,Scotland), 129, 102108. https://doi.org/10.1016/j.tube.2021.102108
6. Hu Y#*, Cheng M#, Liu B, Dong J, Sun L, Yang J, Yang F*, Chen X*, Jin Q*. Metagenomic analysis of the lung microbiome in pulmonary tuberculosis - a pilot study. Emerg Microbes Infect. 2020 Dec;9(1):1444-1452.
7. Zhu J, Guo J, Xu Y, Chen X*. Viral dynamics of SARS-CoV-2 in saliva from infected patients. J Infect. 2020 Sep;81(3):e48-e50. Epub 2020 Jun 25.
8. Yang Q, Zhang M, Chen Q, Chen W, Wei C, Qiao K, Ye T, Deng G, Li J, Zhu J, Cai Y, Chen X*, Ma L*. Cutting Edge: Characterization of Human Tissue-Resident Memory T Cells at Different Infection Sites in Patients with Tuberculosis. J Immunol. 2020 May 1;204(9):2331-2336.
9. Wang W#, Cai Y#, Deng G, Yang Q, Tang P, Wu M, Yu Z, Yang F, Chen J, Werz O*, Chen X*. Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions. mSphere. 2020 Apr 22;5(2). pii: e00263-20.
10. Ouyang Q, Zhang K, Lin D, Feng CG, Cai Y*, Chen X*. Bazedoxifene Suppresses Intracellular Mycobacterium tuberculosis Growth by Enhancing Autophagy. mSphere. 2020 Apr 8;5(2). pii: e00124-20.
11. Hu Y#, Kang Y#, Liu X#, Cheng M#, Dong J, Sun L, Zhu Y, Ren X, Yang Q, Chen X*, Jin Q*, Yang F*. Distinct lung microbial community states in patients with pulmonary tuberculosis. Sci China Life Sci. 2020 Apr 14.
12. Yang Q, Chen Q, Zhang M, Cai Y, Yang F, Zhang J, Deng G, Ye T, Den Q, Li G, Zhang H, Yi Y, Huang R*, Chen X*. Identification of eight-protein biosignature for diagnosis of tuberculosis. Thorax. 2020 Mar 22. pii: thoraxjnl-2018-213021.
13. Cai Y#, Dai Y#, Wang Y#, Yang Q, Guo J, Wei C, Chen W, Huang H, Zhu J, Zhang C, Zheng W, Wen Z, Liu H, Zhang M, Xing S, Jin Q, Feng CG, Chen X*. Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis. EBioMedicine. 2020 Feb 26;53:102686.
14. Hu Y, Wen Z, Liu S, Cai Y, Guo J, Xu Y, Lin D, Zhu J, Li D, Chen X*. Ibrutinib suppresses intracellular mycobacterium tuberculosis growth by inducing macrophage autophagy. J Infect. 2020 Mar 11. pii: S0163-4453(20)30115-8
15. Dai Y#, Cai Y#, Wang X, Zhu J, Liu X, Liu H, Li L, Zhang Y, Liu S, Wen Z, Feng CG, Chen X*, Tang X*. Autoantibody-Mediated Erythrophagocytosis Increases Tuberculosis Susceptibility in HIV Patients. mBio. 2020 Feb 25;11(1). pii: e03246-19.
16. Wang W#, Deng G#, Zhang G, Yu Z, Yang F, Chen J, Cai Y, Werz O*, Chen X*. Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population. Cytokine. 2020 Mar; 127:154956.
17. Dai Y, Shan W, Yang Q, Guo J, Zhai R, Tang X, Tang L, Tan Y, Cai Y, Chen X*. Biomarkers of iron metabolism facilitate clinical diagnosis in Mycobacterium tuberculosis infection. Thorax. 2019 Dec;74(12):1161-1167.
18. Zhu C#, Cai Y#, Zhu J, Zhang L, Xing A, Pan L, Jia H, Mo S, Feng CG, Shen H, Chen X*, Zhang Z*. Histone deacetylase inhibitors impair the host immune response against Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2019 Sep;118:101861
19. Yang Q#, Liao M#, Wang W, Zhang M, Chen Q, Guo J, Peng B, Huang J, Liu H, Yahagi A, Xu X, Ishihara K, Cooper A, Chen X*, Cai Y*. CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. mBio. 2019 Aug 27;10(4). pii: e01949-19.
20. Zhang K, Wang X, Tu J, Rong H, Werz O, Chen X*. The interplay between depression and tuberculosis. J Leukoc Biol. 2019 Sep;106(3):749-757
21. Hu Y#, Yang Q#, Liu B#, Dong J, Sun L, Zhu Y, Su H, Yang J, Yang F*, Chen X*, Jin Q*. Gut microbiota associated with pulmonary tuberculosis and dysbiosis caused by anti-tuberculosis drugs. J Infect. 2019 Apr;78(4):317-322.
22. Dai Y, Wen Z, Ye T, Deng G, Zhang M, Deng Q, Yang Q, Shan W, Kornfeld H, Cai Y, Chen X*. Empirical treatment with non-anti-tuberculosis antibiotics decreased microbiological detection in cervical tuberculous lymphadenitis. Diagn Microbiol Infect Dis. 2018 Nov;92(3):245-249
23. Liu X, Hou X, Gao L, Deng G, Zhang M, Deng Q, Ye T, Yang Q, Zhou B, Wen Z, Liu H, Kornfeld H, Chen X*. Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid. Infect Dis Poverty. 2018 Mar 24;7(1):22.
24. Cheng C, Wang B, Gao L, Liu J, Chen X*, Huang H*, Zhao Z*. Next generation sequencing reveals changes of the γδ T cell receptor repertoires in patients with pulmonary tuberculosis. Sci Rep. 2018 Mar 2;8(1):3956.
25. Zhang G, deWeerd NA, Stifter SA, Liu L, Zhou B, Wang W, Zhou Y, Ying B, Hu X, Matthews AY, Ellis M, Triccas JA, Hertzog PJ, Britton WJ, Chen X*, Feng CG*. A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans. Nat Commun. 2018 Jan 8;9(1):85.
26. Zeng G*, Zhang G*, Chen X*. Th1 cytokines, true functional signatures for protective immunity against TB? Cell Mol Immunol. 2017 Nov 20.
27. Liu X#, Yang Z#, Yuan J, Liao J, Duan L, Wang W, Zhang F, Chen X*, Zhou B*. Early Antibody Response Contributes to the Virus Eradication and Clinical Recovery of H7N9 Influenza Infection. Ann Clin Lab Sci. 2017 Sep;47(5):592-599.
28. Li X, Yang Q, Feng B, Xin H, Zhang M, Deng Q, Deng G, Shan W, Yue J, Zhang H, Li M, Li H, Jin Q, Chen X*, Gao L*. Tuberculosis infection in rural labor migrants in Shenzhen, China: Emerging challenge to tuberculosis control during urbanization. Sci Rep. 2017 Jun 30;7(1):4457.
29. Mishra BB, Lovewell RR, Olive AJ, Zhang G, Wang W, Eugenin E, Smith CM, Phuah JY, Long JE, Dubuke ML, Palace SG, Goguen JD, Baker RE, Nambi S, Mishra R, Booty MG, Baer CE, Shaffer SA, Dartois V, McCormick BA, Chen X*, Sassetti CM*. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017 May 15;2:17072.
30. Deng W#, Long Q#, Zeng J, Li P, Yang W, Chen X*, Xie J*. Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense. Sci Rep. 2017 Apr 25;7:46716. doi: 10.1038/srep46716.
31. Zhang GL#, Liu X#, Wang WF, Cai Y, Li SY, Chen Q, Liao MF, Zhang MX, Zeng GC, Zhou BP, Feng CG, Chen XC*. Down-regulation of miR-20a-5p triggers cell apoptosis to facilitate mycobacterial clearance through targeting JNK2 in human macrophages. Cell Cycle. 2016, 15(18):2527-38.
32. Jiang J, Chen XC*, An HJ, Yang BF, Zhang FP, Cheng XX*. Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling. Scientific Reports. 2016, 6.
33. Cai Y#, Yang QT#, Liao MF#, Wang H#, Zhang C, Nambi S, Wang WF, Zhang MX, Wu JY, Deng GF, Deng QY, Liu HY, Zhou BP, Jin Q, Feng CG, Sassetti CM, Wang FD*, Chen XC*. xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation. Oncotarget. 2016, 7(21):31001-13.
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l
共同作者论文：
（# 井号标注的为共同第一作者，* 星号标注的为通讯作者/共同通讯作者；IF 为杂志影响因子；申请者以下划线标出）
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论著编写
1) 周育森，周伯平，陈心春 （编写）。 SARS冠装病毒病原学。见：周伯平，唐小平，陆普选主编。《传染性非典型肺炎》。北京：人民卫生出版社.2004，P10-27
2) 周育森，赵光宇，周伯平，陈心春（副主编）。H5N1禽流感病毒病原学. 见： 周伯平，黎毅敏，陆普选 主编 《人禽流感 》北京：科学出版社. 2007, P8-41
3) 陈心春(副主编)，张国良. EV71病原学. 见：周伯平，李成荣主编. 《肠道病毒71型手足口病》.北京：人民卫生出版社.2009，P12-33
指南撰写
1) γ干扰素释放试验在中国应用的建议。 《中华结核病和呼吸杂志》2014. （通讯作者）
会议交流:
2014.05: Zhang G, Zhou B, Li S, Yue J, Yang H, Wen Y, Zhan S, Wang W, Liao M, Zhang M, Zeng G, Feng CG, Sassetti CM, Chen X*. Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to increased tuberculosis susceptibility. The 101th annual meeting of American Association of Immunologists, May 2-6, Pittsburgh, USA
2010.05: Chen X, Zhang M, Zhou B. Reduced Th17 response in patients with tuberculosis is associated with decreaded IL-6R expression on CD4 T cells. The 97th annual meeting of American Association of Immunologists, May 7th-11th, Baltimore, USA
2008.11: Chen X, Yang Q, Zhou B, et al. Diagnosis of latent TB infection by using in-house Interferon-gamma ELISPOT in Shenzhen, China. Invited speaker at Second Ditan International Conference on Infectious Diseases. Nov. 14-17, Beijing, China
2008.06: Chen X, Zhang M, Li M, et al. Mycobacterium Tuberculosis Derived Toll-like Receptor 2 Ligand Modulate the Function of CD4 T Cells Directly. Oral presentation at the 8th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2008), June 5-9, Boston, USA
2004.12: Chen X, Zeng Y, Li G, Thompson S, Sepassi M, Romanoski M.A, Graner M.W, Katsanis E. Tumor-derived chaperone-rich cell lysate (CRCL) can be effectively combined with syngeneic bone marrow transplantation to treat bcr-abl+ leukemia in a murine model. Presented at the American Society of Hematology, San Diego, California, USA
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