陈璇导师简介

基本信息：博士，南昌医学院 基础医学院，讲师

联系方式：电话：18779883120

                       邮箱：chenxuan01@ncmc.edu.cn

研究领域：

1. 表观遗传修饰调控真菌毒素合成的机制；

2. 表观遗传修饰调控病原抗性的机制。

近五年主持的基金项目/课题：

(1) 国家自然科学基金地区科学基金项目，32660018，异染色质蛋白HepA通过温度响应招募RmtC调控黄曲霉毒素合成的分子机制，2027-01-01至2030-12-31，32万，在研，主持；

(2) 病原体与宿主相互作用教育部重点实验室开放课题，KFKT2025-0004，恶性疟原虫非编码RNARUF6与组蛋白伴侣分子PfNapS协同调控致病基因表达的机制研究，2025-03-01至2027-02-28，5万元，在研，主持；

(3) 江西省职业早期青年科技人才培养项目，20244BCE52258，赭曲霉毒素的合成调控机制研究，2025-01-01至2029-12-31，20万元，在研，主持；

(4) 江西省自然科学基金青年项目，20242BAB20250，乙酰化修饰调控赭曲霉毒素合成的分子机制，2024-06-01至2027-05-31，10万元，在研，主持；

(5) 博士科研启动项目，NYB24005，乙酰转移酶GcnE家族调控赭曲霉毒素合成的分子机制，2024-12-01至2027-12-31，10万元，在研，主持。

代表性论著：

[1] Chen Xuan^#, Huang Shuqi^#, Jiang Zhiwei, Zhang Yuqi, Wang Shihua^*. Lysine benzoylation of fatty acid β-oxidation core enzyme FoxA regulates the aflatoxin biosynthesis by benzoyltransferase EsaA in the pathogenic fungus Aspergillus flavus. mBio. 2026, 17(5): e0367225.

[2] Chen Xuan, Zhang Yuqi, Luo Wenxin, Wang Shihua^*. The benzoylation of the splicing factor Skip is critical for development, oxidative stress response and pathogenicity in Aspergillus flavus. Toxins. 2026, 18(2): 83.

[3] Yu Xinyu^#, He Jincan^#, Wang Changhong^#, Mu Jianbing^#, Chen Xuan^#, Zhao Yuemeng, He Xiaohui, Liu Sihong, Sa Juliana M, Platon Lucien, Tang Jianxia, Si Wenwen, Tang Ruoyu, Menard Didier^*, Wellems Thomas E^*, Jiang Cizhong^*, Cao Jun^*, Zhang Qingfeng^*. Epigenetically conferred ring-stage survival in Plasmodium falciparum against artemisinin treatment. Nature Communications. 2025, 16(1): 8037.

[4] Tang Ruoyu^#, Chen Xuan^#, Shang Xiaomin^#, Hu Ye, Lu Binbin, Du Xuli, Yang Junlong, Zhang Fengshuo, Wang Fei, Zhang Zuping, Bai Yanli, Zhang Qingfeng*, Fan Yanting*. m5C methylation of mitochondrial RNA and non-coding RNA by NSUN3 is associated with variant gene expression and asexual blood-stage development in Plasmodium falciparum. Parasite Vectors. 2025, 18(1):121.

[5] Chen Xuan^#, Wu Lihan^#, Zhang Yuqi, Wang Sen, Wang Shihua^*. Importance of benzoyltransferase GcnE and lysine benzoylation of alcohol dehydrogenase AdhB in pathogenesis and aflatoxin production in Aspergillus flavus. mBio. 2025, 16(1): e0266524.

[6] Chen Xuan^#, Wu Lianghuan^#, Lan Huahui^#, Sun Ruilin, Wen Meifang, Ruan Danrui, Zhang Mengjuan, Wang Shihua*. Histone acetyltransferases MystA and MystB contribute to morphogenesis and aflatoxin biosynthesis by regulating acetylation in fungus Aspergillus flavus. Environmental Microbiology. 2022, 24(3): 1340-1361.

[7] Fang Shaoming^#, Chen Xuan^#, Ye Xiaoxing, Zhou Liwen, Xue Shuaishuai, Gan Qianfu^*. Effects of gut microbiome and short-chain fatty acids (SCFAs) on finishing weight of meat rabbits. Frontiers in Microbiology. 2020, 11: 1835.

[8] Fang Shaoming^#, Chen Xuan^#, Pan Jiahua, Chen Qiaohui, Zhou Liwen, Wang Chongchong, Xiao Tianfang, Gan QianFu^*. Dynamic distribution of gut microbiota in meat rabbits at different growth stages and relationship with average daily gain (ADG). BMC Microbiology. 2020, 20(1): 116.

[9] Fang Shaoming^#, Chen Xuan^#, Zhou Liwen, Wang Chongchong, Chen Qiaohui, Lin Ruiyi, Xiao Tianfang, Gan Qianfu^*. Faecal microbiota and functional capacity associated with weaning weight in meat rabbits. Microbial Biotechnology. 2019. 12(6): 1441-1452.

[10] Chen Xuan^#, Fang Shaoming^#, Wei Lili, Zhong Qiwang^*. Systematic evaluation of the gut microbiome of swamp eel (Monopterus albus) by 16S rRNA gene sequencing. PeerJ. 2019, 7: e8176.

[11] Chen Xuan^#, Lai Chongde^#, Wang Yulan, Wei Lili, Zhong Qiwang^*. Disinfection effect of povidone-iodine in aquaculture waer of swamp eel (Monopterus albus). PeerJ. 2018, 6: e5523.