尹芝南导师简介

姓  名： 尹芝南

出生日期：1964 年 10 月 1  日

国  籍 ：中国

联系方式： 18818801179  （手机）  020-85222787  （办公室）  020-85222787  （传真）

地  址:   广东省广州市黄埔大道西 601 号暨南大学教育学院大楼（暨大北门）10 楼办公室

目前职位： 暨南大学生物医学转化研究院院长、教授、博导

珠海市人民医院（暨南大学附属医院）学术总监

邮  箱： tzhinan@jnu.edu.cn

教育背景： 1979.09—1984.07         医学学士  湖北医科大学（武汉大学医学院）

1985.09—1988.08        硕士     上海第二医科大学（上海交通大学医学院）

1994.12—1997.12        博士      德国柏林自由大学

职业经历： 1984.09—1985.08         助教     郧阳医学院微生物免疫教研室（湖北医药大学）

       1988.09—1992.12         讲师     广州医学院微生物学免疫学教研室（广州医科大学）

                      1992.12—1994.12      访问学者   意大利国家肿瘤中心

        1994.12—1997.12  博士            德国柏林自由大学（1997 年获得学位）

       1997.12—1999.03       博士后    耶鲁大学医学院风湿科

1999.03—2001.06     助理研究员  耶鲁大学医学院风湿科

2001.07—2006.06     助理教授   耶鲁大学医学院风湿科

2006.07—2007.03     副教授    耶鲁大学医学院风湿科

2007.03—2011.11     院长      南开大学生命科学学院

2007.03—2013.07     教授      南开大学生命科学学院

           兼职副教授  耶鲁大学医学院风湿科

2013.07—至今   教授、院长  暨南大学生物医学转化研究院

           （长江学者）

2019.09—至今   学术总监   珠海市人民医院（暨南大学附属医院）

1. 国家或地区级奖项：

- 1988 年全国硕士研究生优秀论文评选优秀论文一等奖（中国微生物学会）论 文题目“β-D  半乳糖苷酶/抗 β-D  半乳糖苷酶单克隆抗体复合体(GAG)及其在 ELISA 和免疫组化中的应用”。

- 2000 年获得美国国家风湿病基金会青年基金。

- 2000 年加入耶鲁癌症中心。

- 2000 年加入美国风湿病学会（ACR）。

- 2002 年加入美国免疫学会（AAI）。

- 2002 年加入美国癌症研究协会（AAC）。

- 2004 年获得美国免疫学家协会（AAI）青年教授会议资助奖。

- 2007 年获得国家自然科学基金杰出青年基金。

- 2007 年由中国教育部任命为“长江学者”特聘教授。

- 2009 年获得天津市“创业领军人才”。

- 2010 年获得国家人力资源和社会保障部“高层次海外留学归国创业人才”。

- 2013 年获得国家人力资源和社会保障部新“百千万”人才工程“有突出贡献 中青年专家”。

- 2013 年获得广东省第四批引进创新创业团队带头人。

- 2014 年获得中国侨联第五届中国侨界（创新人才）贡献奖。

- 2018 年获得第十四届广东省丁颖科技奖。

- 2018 年获得中国侨界侨联贡献奖二等奖。

- 2020 年获得广东省科技进步奖一等奖（第五完成人）。

-2021 年获得中国 2021 年度重要医学进展（基础医学与生物学领域）：发现 IL-27 信号调控肥胖和 2 型糖尿病的新机制。

2.  机构奖项：

-  耶鲁大学医学院“布朗核心奖学金”

- 2001 年获得耶鲁癌症中心癌症研究奖。

- 2006 年获得耶鲁大学医学院内科系科研成就奖。

- 2019 年获得暨南大学外事工作先进个人奖、重大科研成果奖。

研究领域：

1）γδ T 细胞功能分化的分子机制及其在肿瘤免疫中的作用；

2）IL-27 的免疫学机制研究；

3）癌症和炎症疾病的小分子药物发现及其作用机制；

4）肠道菌群同 γδ T 细胞之间具有相互调控作用；

承担的基金项目：

1）“Yδ T 细胞分化的机制和功能”，NIH 基金项目，基金编号：1 R01 AI56219-01， 2004 年 1 月 15  日-2008 年 12 月 31  日，总资助额度：143.06 万美元；

2）“Yδ T 细胞分化的调控和功能”，NIH 基金项目，基金编号：1 K01 AR02188-05， 2004 年 3 月 1  日-2006 年 2 月 28  日，总资助额度：68.57 万美元；

3） “Yδ T 细胞分化的调控和功能”，美国国家风湿病协会基金项目，基金编号： 研究基金，2004 年 7 月 1  日-2006 年 6 月 30  日，总资助额度：40.50 万美元；

4）“Yδ T 细胞分化的机制和功能”，NIH 基金项目，基金编号：1 R21 AI 56219-01， 2003 年 7 月 15  日—2004 年 7 月 14  日，总资助额度：32.70 万美元；

5）“Yδ T 细胞在肉瘤纤维化中的作用”，NIH 基金项目，基金编号：5P30

AR041942-090024 ，2002 年 4 月 1  日—2003 年 3 月 31  日，总资助额度：3.27 万 美元；

6）“Yδ T 细胞的分子机制和功能”，美国国家风湿病协会基金项目，基金编号： 博士后基金，2000 年 7 月 1  日-2001 年 6 月 30  日，总资助额度：3.27 万美元；

7）“Yδ T 细胞在肿瘤免疫中的功能”，耶鲁癌症中心，基金编号：癌症研究奖， 2000 年 7 月 1  日-2001 年 6 月 30  日，总资助额度：2.50 万美元；

8）“Yδ T 细胞在系统性红斑狼疮中的作用”，耶鲁大学医学院，基金编号：布 朗核心博士后研究基金，1998 年 7 月 1  日—1999 年 6 月 30  日，总资助额度：2.80 万美元；

9）肿瘤和免疫细胞相互作用过程中蛋白质的功能研究，科技部国家重点基础研 究发展计划 经费：2500 万(896.21 万)，项目起至时间： 2007-7—2011-7  项目完 成人：尹芝南、董金堂、白钢、向荣、曹又佳、赵立青、朱玉山、李登文、朱正 茂、叶丽虹、张涛、张晓东等  2007CB914800

10) 自身免疫识别与应答的机制，国家自然科学基金 重大项目 子课题 经费：280 万，项目起至时间： 2009-1—2012.12 ， 项目完成人：尹芝南、王璞玥、张 弛、赵立青、林育泉等  30890143

11) γδT  细胞分化及其在肿瘤免疫中的作用，国家自然科学基金 国家杰出青年基 金经费：200 万，项目起至时间： 2008-1—2011.12    项目完成人：尹芝南  30725015

12)  乳腺癌的疫苗研制，天津市科技支撑计划重点项目   经费：50 万，项目起 至时间：2007-10—2009.10 项目完成人：尹芝南、周卫红、郝健磊、李峥、武晓 丽  07ZCKFSH03600

13)  “973 ”国家科技计划：类风湿性关节炎发病的免疫学机制及其干预策略的 研究  2010.01-2014.08    230 万 项目编号：2010CB529100

14) “类风湿性关节炎分子机制的联合研究”，科技部国际科技合作计划，经费： 290 万。项目起止时间，2011-01-01-2013-12-31。项目负责人。2010DFB34000

15) γδ T 细胞在肝脏天然免疫应答中的作用，国家自然科学基金重点项目，总经 费，325 万，南开大学243 万，中国科技大学 82 万，项目起止年月：2013.01-2017.12。 项目负责人：尹芝南，项目编号：31230025

16) “重大疾病临床诊断试剂研发”，广东省第四批引进创新创业团队项目，团 队带头人，经费：1000 万元。201301S0105240297

17) “γδ T 细胞与肠道菌群之间的相互调控及其分子机制”，国家自然科学基金 重大国际合作项目，项目负责人，经费：289 万元。31420103901

18) “γδ T 细胞和IL-27 在脂肪肝中的作用及其分子机制”， 广东省自然科学  基金重大培育项目，2015-2017，项目负责人，经费：100 万元。2014A030308003

19) “具有人类造血免疫系统的人源化动物模型的研发及其转化应用 ” 科技部

863 计划，2014-2016 ，750 万元

20）结核及结核合并慢性病毒感染的创新诊断和治疗研究。广州市科信局， 健康 医疗协同创新重大专项，201607-201906, 650 万元，201510201011371

21)  尹芝南，免疫功能调控的分子机制创新引智基地. 国家外专局、教育部“111” 创新引智基地. B16021, 900 万，2016-2020.

22）尹芝南，γδ T 细胞介导肿瘤免疫的分子机制，国家自然科学基金委重点项目， 项目编号 31830021。2019-2023，282 万，负责人。

23）尹芝南，粤港澳大湾区转化医学博士培养项目，国家留学基金委 2020 年创 新项目“双一流”建设高校专项。2020-2022 年。

24）国家自然科学基金 重点项目 IL-17+γδT 细胞发育及分化的代谢调控分子 机制   32030036     尹芝南 202009  202101-202512   304 万

25) 国家科学技术部   国家重点研发计划 免疫调节对肠道细胞发育分化及其 功能的作用及机制 2020YFA0803502     尹芝南 202011 202011-202510    749 万

发表的文章：

第一作者及通讯作者文章

[1] Yin Z, Gabriele E, Leprini A, Perris R, Colombatti A. Differential cation regulation of the alpha 5 beta 1 integrin-mediated adhesion of leukemic cells to the central cell-binding domain offibronectin[J]. Cell Growth Differ, 1997,8(12): 1339-47.

[2] Yin Z, Braun J, Neure L, Wu P, Liu L, Eggens U, Sieper J. Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis[J]. Arthritis Rheum, 1997, 40(10):1788-97.

[3] Yin Z, Braun J, Neure L, Wu P, Eggens U, Krause A, Kamradt T, Sieper J. T cell  cytokine pattern in the joints of patients with Lyme arthritis and its regulation by cytokines and anticytokines[J]. Arthritis Rheum, 1997, 40(1): 69-79.

[4] Müller B, Gimsa U, Mitchison N A, Radbruch A, Sieper J, Yin Z. Modulating the Th1/Th2 balance in inflammatory arthritis[J]. Springer Semin Immunopathol, 1998, 20(1-2): 181-96.

[5] Yin Z, Giacomello E, Gabriele E, Zardi L, Aota S, Yamada K M, Skerlavaji B, Doliana R, Colombatti A, Perris R. Cooperative activity of alpha4beta1 and alpha4beta7 integrins in mediating human B-cell lymphoma adhesion and chemotaxis on fibronectin through recognition of multiple synergizing binding sites within the central cell-binding domain[J]. Blood, 1999, 93(4): 1221-30.

[6] Yin Z, Siegert S, Neure L, Grolms M, Liu L, Eggens U, Radbruch A, Braun J,Sieper J. The elevated ratio of interferon gamma-/interleukin-4-positive T cells found in synovial fluid and synovial membrane of rheumatoid arthritis patients can be changed by interleukin-4 but not by interleukin-10 or transforming growth factor beta[J]. Rheumatology (Oxford), 1999, 38(11): 1058-67.

[7] Yin Z, Craft J. gamma delta T cells in autoimmunity[J].Springer Semin Immunopathol, 2000, 22(3): 311-20.

[8] Yin Z, Zhang D H, Welte T, Bahtiyar G, Jung S, Liu L, Fu X Y, Ray A, Craft J.Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression[J]. JImmunol, 2000, 164(6): 3056-64.

[9] Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert M E, Mcniff J, Madaio M P, Craft J. IL-10 regulates murine lupus[J]. JImmunol, 2002, 169(4): 2148-55.

[10] Yin Z, Chen C, Szabo S J, Glimcher L H, Ray A, Craft J. T-Bet expression and   failure of GATA-3 cross-regulation lead to default production ofIFN-gamma by gammadelta T cells. JImmunol, 2002, 168(4): 1566-71.

[11] Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht L H, Craft J, Yin Z.Gamma delta T cells provide an early source of interferon gamma in tumor immunity. JExp Med, 2003, 198(3): 433-42.

[12] Pan M, Kang I, Craft J, Yin Z. Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary,    immune response. J Clin Immunol, 2004, 24(5): 481-91.

[13] Gao Y, Tao J, Li M O, Zhang D, Chi H, Henegariu O, Kaech S M, Davis R J,Flavell R A, Yin Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. JImmunol, 2005, 175(9): 5783-9.

[14] Gao Y, Zhang D, Sun B, Fujii H, Kosuna K, Yin Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and    adaptive immune responses. Cancer ImmunolImmunother, 2006, 55(10):1258-66.

[15] You X, Pan M, Gao W, Shiah H S, Tao J, Zhang D, Koumpouras F, Wang S,Zhao H, Madri J A, Baker D, Cheng Y C, Yin Z. Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response. Arthritis Rheum, 2006, 54(3): 877-86.

[16] Chen L, He W, Kim S T, Tao J, Gao Y, Chi H, Intlekofer A M, Harvey B, Reiner  S L, Yin Z, Flavell R A, Craft J. Epigenetic and transcriptional programs lead to    default IFN-gamma production by gammadelta T cells. JImmunol, 2007, 178(5): 2730-6.

[17] Tao J, Gao Y, Li M O, He W, Chen L, Harvev B, Davis R J, Flavell R A, Yin Z.JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Eur JImmunol, 2007, 37(3): 818-29.

[18] Hao J, Wu X, Xia S, Li Z, Wen T, Zhao N, Wu Z, Wang P, Zhao L, Yin Z.Current progress in γδ T-cell biology. Cell Mol Immunol, 2010, 7(6): 409-13.

[19] He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'brien R L, Born W K, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin. JImmunol, 2010, 185(1): 126-33.

[20] Yin Z, Fujii H, Walshe T. Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor  necrosis factor-α in healthy adults. Hum Immunol, 2010, 71(12): 1187-90.

[21] Hao J, Dong S, Xia S, He W, Jia H, Zhang S, Wei J, O'brien R L, Born W K, Wu Z, Wang P, Han J, Hong Z, Zhao L, Yin Z. Regulatory role of Vγ1 γδ T cells in   tumor immunity through IL-4 production. JImmunol, 2011, 187(10): 4979-86.

[22] Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, Zhang W, Tan S, Pandey V, Yao Y, Wang P, Zhao L, Wang J, Wu Q, Song E, Lobie P E, Yin Z, Zhu T. Pivotal role  of reduced let-7g expression in breast cancer invasion and metastasis.Cancer Res, 2011, 71(20): 6463-74.

[23] Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft J E, Flavell R A, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Res Ther, 2011, 13(6): R212.

[24] Zhao N, Hao J, Ni Y, Luo W, Liang R, Cao G, Zhao Y, Wang P, Zhao L, Tian Z, Flavell R, Hong Z, Han J, Yao Z, Wu Z, Yin Z. Vγ4 γδ T cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis. JImmunol, 2011, 187(10): 5007-14.

[25] Lin Y, Wen T, Meng X, Wu Z, Zhao L, Wang P, Hong Z, Yin Z. The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells. Biochem J, 2012, 443(3): 779-88.

[26] Wang H, Wei J, Yang C, Zhao H, Li D, Yin Z, Yang Z. The inhibition of tumor growth and metastasis by self-assembled nanofibers of taxol. Biomaterials, 2012, 33(24): 5848-53.

[27] Wen T, Li Y, Wu M, Chen X, Han L, Bao X, Wang Z, Wang K, Hu Y, Zhou X, Wu Z, Wang P, Hong Z, Zhao L, Wang Q, Yin Z. A novel tylophorine analog    NK-007 ameliorates colitis through inhibition of innate immune response.Int Immunopharmacol, 2012, 14(4): 487-94.

[28] Wen T, Li Y, Wu M, Sun X, Bao X, Lin Y, Hao J, Han L, Cao G, Wang Z, Liu Y, Wu Z, Hong Z, Wang P, Zhao L, Li Z, Wang Q, Yin Z. Therapeutic effects of a novel tylophorine analog, NK-007, on collagen-induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation. Arthritis Rheum, 2012, 64(9): 2896-906.

[29] Chen X, Wen T, Wei J, Wu Z, Wang P, Hong Z, Zhao L, Wang B, Flavell R,Gao S, Wang M, Yin Z. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cell Mol Immunol, 2013, 10(6): 497-505.

[30] Li Y, Wen T, Zhu M, Li L, Wei J, Wu X, Guo M, Liu S, Zhao H, Xia S, Huang W, Wang P, Wu Z, Zhao L, Shui W, Li Z, Yin Z. Glycoproteomic analysis of   tissues from patients with colon cancer using lectin microarrays and nanoLC-MS/MS. Mol Biosyst, 2013, 9(7): 1877-87.

[31] Meng X, Zhang Y, Jia Z, Huo X, He X, Tian G, Wu M, Wang Z, Zhou X, Xiong S, Gao X, Wu Z, Han J, Zhao L, Wang P, Hong Z, Wang Q, Yin Z. A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis. J Leukoc Biol, 2013, 93(1): 83-93.

[32] Wei J, Xia S, Sun H, Zhang S, Wang J, Zhao H, Wu X, Chen X, Hao J, Zhou X,  Zhu Z, Gao X, Gao J X, Wang P, Wu Z, Zhao L, Yin Z. Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells. JImmunol, 2013, 191(1): 500-8.

[33] Wu X, Zhang J Y, Huang A, Li Y Y, Zhang S, Wei J, Xia S, Wan Y, Chen W,Zhang Z, Li Y, Wen T, Chen Y, Tanaka Y, Cao Y, Wang P, Zhao L, Wu Z,    Wang F S, Yin Z. Decreased Vδ2 γδ T cells associated with liver damage by  regulation of Th17 response in patients with chronic hepatitis B. J Infect Dis, 2013, 208(8): 1294-304.

[34] Zhang S, Liang R, Luo W, Liu C, Wu X, Gao Y, Hao J, Cao G, Chen X, Wei J, Xia S, Li Z, Wen T, Wu Y, Zhou X, Wang P, Zhao L, Wu Z, Xiong S, Gao X,Gao X, Chen Y, Ge Q, Tian Z, Yin Z. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+ T cells. Hepatology, 2013, 57(4): 1620-31.

[35] Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech S M,Weaver C T, Flavell R A, Zhao L, Yao Z, Yin Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol, 2013, 94(6): 1103-12.

[36] Mao X, Wu Y, Diao H, Hao J, Tian G, Jia Z, Li Z, Xiong S, Wu Z, Wang P,Zhao L, Yin Z. Interleukin-6 promotes systemic lupus erythematosus progression  with Treg suppression approach in a murine systemic lupus erythematosus model. Clin Rheumatol, 2014, 33(11): 1585-93.

[37] Xia S, Wei J, Wang J, Sun H, Zheng W, Li Y, Sun Y, Zhao H, Zhang S, Wen T, Zhou X, Gao J X, Wang P, Wu Z, Zhao L, Yin Z. A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells. J Leukoc Biol, 2014, 95(5): 733-742.

[38] Zhao N, Ni Y, Zhao L, Wu Z, Yin Z. [Protective role of γδ T cells in concanavalin A-induced liver injury]. Zhonghua Gan Zang Bing Za Zhi, 2014, 22(1): 58-62.

[39] Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORγt and STAT3. JImmunol, 2014, 192(12): 5599-609.

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