吴熠导师简介

吴熠  

博士，硕士研究生导师，副教授，中国中医药信息学会中医临床药学分会常务理事，中国民族医药学会远程教育分会常务理事，Phytomedicine，Natural Product Communication和Medicinal Chemistry Research等主流杂志的审稿人。主持并完成国家自然科学基金1项，省部级基金1项，横向课题多项。长期从事药物设计学、药物化学、网络药理学、人工智能等交叉学科的研究工作。近年来，以临床重大疾病的治疗需求为导向，积极开展退行性和心脑血管疾病等多发于老年人的共病研究。通过网络药理学、AI辅助的药靶亲合力评估、AI辅助药物分子设计等多种研究策略的联用，实现“老药新用”和创新先导化合物的发现及结构优化。在此基础上，采用果蝇等模式动物，应用分子生物学等手段阐明其作用机理，探索获得具有临床应用前景的候选药物分子。近三年（2022-2024），以第一作者或通讯作者发表sci论文8篇，参与3篇。

联系方式：

E-mail：wuyi@gmu.edu.cn 

电话：13125357621

教育及工作经历：

2020~至今 赣南医科大学心脑血管疾病防治教育部重点实验室特聘研究人员

2014~2020 井冈山大学 医学部 教师

2007~2013 四川大学华西药学院，天然药物化学，硕/博连读

2003~2007 四川大学华西药学院，药学，本科

 

主要研究方向：

1. 人工智能辅助的网络药理学研究；

2. AIDD和CADD药物分子设计、合成及活性评价。

近三年（2022-2024）已发表的SCI论文：

1、Wu Y*, Zhang H, Wang Q, Tang P, Jiang D, Mo J, Qiu H, He L*, Zhang M*. (2024) Ring-Opening Coupling of Cyclopropanol with 1,2,3-Triazole for the Synthesis of Fused Triazoles. Org Lett. 2024 May 17;26(19):4043-4048. doi: 10.1021/acs.orglett.4c00702. Epub 2024 May 2. (中科院一区top，一作兼通讯).

2、Ye H, Li ZQ, Yang JM, Long Y, Zhong YB, Wu Y*, Wang MY*. (2024) A network pharmacology-based study to investigate the mechanism of curcumin-regulated regenerative repair of quadriceps femoris muscle in KOA rats. Eur J Pharmacol. 2024 Aug 16:176910. doi: 10.1016/j.ejphar.2024.176910. Epub ahead of print. (中科院二区，共同通讯).

3、Long Y†, Wu Y†, Li ZQ, Ye H, Yang JM, Zhong YB, Wang MY. (2024)  Resveratrol as a Potential Therapeutic Agent for Sarcopenic Obesity: Insights from In Vivo Experiments. Biomed Pharmacother. 2024 Aug; Accept. (中科院一区，共同一作)

4、Cao J, Luo Y, Chen Y, Wu Z, Zhang J, Wu Y*, Hu W*. (2024) Maternal mitochondrial function affects paternal mitochondrial inheritance in Drosophila. Genetics. 2024 Apr 3;226(4):iyae014. doi: 10.1093/genetics/iyae014. (中科院三区，共同通讯)

5、Xie R, Chen F, Ma Y, Hu W, Zheng Q, Cao J* and Wu Y* (2023) Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer’s disease. Front. Pharmacol. 14:1249632. doi: 10.3389/fphar.2023.1249632 (中科院二区，通讯)

6、Wu Y*, Ma Y, Cao J, Xie R, Chen F, Hu W*, Huang Y*. (2023) Feasibility study on the use of "Qi-tonifying medicine compound" as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking. Front Nutr. 2023 May 5;10:1131972. doi: 10.3389/fnut.2023.1131972. (中科院二区，一作兼通讯)

7、Chen F, Wu Y*, Ma Y, Yin H, Su F, Huang R, Wu X, Liu Q*. (2023) Synthesis, radiolabeling, and evaluation of ⁶⁸Ga-labeled aminoquinoxaline derivative as a potent PFKFB3-targeted PET tracer. Front Chem. 2023 Mar 22;11:1158503. doi: 10.3389/fchem.2023.1158503. (中科院三区，共同通讯)

8、Wang S, Ma Y, Huang Y, Hu Y*, Huang Y*, Wu Y*.(2022)  Potential bioactive compounds and mechanisms of Fibraurea recisa Pierre for the treatment of Alzheimer's disease analyzed by network pharmacology and molecular docking prediction. Front Aging Neurosci. 2022 Dec 8;14:1052249. doi: 10.3389/fnagi.2022.1052249. (中科院二区，通讯)

9、Pan Lili; He Qian; Wu Yi; Zhang Ni; Cai Huawei; Yang Bo; Wang Yuxi; Li Yunchun; Wu Xiaoai; (2022) Synthesis, radiolabeling, and evaluation of a potent β-site APP cleaving enzyme (BACE1) inhibitor for PET imaging of BACE1 in vivo. Bioorganic & Medicinal Chemistry Letters, 2022, 59(1)  (中科院二区，IF 2.7，参与).

10、Huang J, Wu Y, Hu Z, Han S, Rong L, Xie X, Chen W*, Peng X*.(2023)  Mn(OAc)₂-promoted [3+2] cyclization of enaminone with isocyanoacetate: Rapid access to pyrrole-2-carboxylic ester derivatives with potent anticancer activity. Bioorg Chem. 2023 Jul 28;140:106748. doi: 10.1016/j.bioorg.2023.106748. (中科院一区，参与)

11、Wang MY, Yang JM, Wu Y, Li H, Zhong YB, Luo Y, Xie RL.(2024) Curcumin-activated Wnt5a pathway mediates Ca2+ channel opening to affect myoblast differentiation and skeletal muscle regeneration. J Cachexia Sarcopenia Muscle. 2024 Jul 10. doi: 10.1002/jcsm.13535. Epub ahead of print. PMID: 38982896. (中科院一区top，参与)