钟佳宁导师简历
钟佳宁，男，1981年出生。2004年毕业于南昌大学获生物学学士学位，2011年硕博连读毕业于首都师范大学，获理学博士学位。导师许兴智教授。2011年至2016年任职温州医学院基因组医学研究院助理研究员。2016年至今任职赣南医学院副教授。目前，主要从事组蛋白修饰在糖尿病以及心脑血管方面的研究。迄今为止共主持国家自然科学基金3项，省自然基金2项，总共发表SCI论文二十几篇。
联系方式：
电话：13387073773
邮箱：zhongning_003@163.com
1、个人简介
钟佳宁，副教授，籍贯江西龙南，2011年首都师范大学遗传学博士毕业，就职于赣南医学院心脑血管疾病防治教育部重点实验室。
2、主要研究领域与方向
1）DNA损伤修复、基因组的稳定性与肿瘤发生的关系；
2）糖尿病等复杂疾病的表观遗传学机制研究；
3、教育经历
2000.9—2005.6 南昌大学生物科学专业本科培养
2006.9—2011.1 首都师范大学硕博士培养
4、研究工作经历
2011.9—2016.10 温州医学院基因组医学研究院助理研究员
2016.10-至今 赣南医学院心脑血管疾病防治教育部重点实验室
5、承担及参与的主要科研项目
1. 国家自然科学基金地区项目，82060363，二甲双胍通过去乙酰化酶SIRT2调控单核细胞增生李斯特菌感染的机制研究，2021/01-2024/12，在研，主持
2. 国家自然科学基金地区项目，81760160，TET1通过SIRT1-PGC1a/FOXO1 调控肝脏能量代谢的机制研究，2018/01-2022/12,在研，主持
3. 国家自然科学基金青年项目，81301778，氧化应激诱导TET1在结肠癌发生中的表观遗传调控机制，2013/01-2016/12，结题，主持
4. 浙江省自然科学基金一般项目， LY13C060002，TETs蛋白调控结肠癌基因组甲基化（5-mC）及羟甲基化（5-hmC）变化研究，2013/06-2016/12，结题，主持
5. 浙江省教育厅项目，Y201223513，Tet1通过调节下游基因甲基化从而调控H2O2诱导的氧化损伤修复通路，2012/06-2015/12，结题，主持
6. 赣南医学院创新团队项目，医学遗传学与行为学研究，2018/1-2020/12，在研，主持
7. 赣南医学院人才启动基金，DNA损伤以及基因组稳定性的机制研究，2017/1-2019/12，在研，主持
6. 江西省国自然面上基金， 20202BAB206086，TET1调控肝癌葡萄糖代谢的机制研究，2021/01-2023/12，在研，主持
6、代表性论文或著作
1. Xianfeng Li#, Leisheng Shi#, Yan Wang#, Jianing Zhong#, Xiaolu Zhao, Huajing Teng, Xiaohui Shi, Haonan Yang, Shasha Ruan, MingKun Li, Zhong Sheng Sun, Qimin Zhan, and Fengbiao Mao. OncoBase: a platform for decoding regulatory somatic mutations in human cancers. 2019. Nucleic acids research. Jan 8; 47: D1044–D1055
2. Jianing Zhong, Xianfeng Li, Wanshi Cai, Yan Wang, Shanshan Dong, Jie Yang, Jian’an Zhang, Nana Wu, Yuanyuan Li, Fengbiao Mao, Cheng Zeng, Jinyu Wu, Xingzhi Xu and Zhong Sheng Sun. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function.2017. Nucleic acids research. Jan 25; 45(2):672-684
3. Zhong J #,*, Ji L, Chen H, Li X, Zhang J, Wang X, Wu W, Xu Y, Huang F, Cai W, Sun ZS. Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress. Int J Biol Sci. 2017 Jul 15;13(7):923-934. doi: 10.7150/ijbs.17260.
4. Bo Wang, Ailian Zhao, Lingling Sun, Xueyan Zhong, Jianing Zhong, Haibo Wang, Minhua Cai, Jing Li,Yi Xu, Ji Liao, Jianli Sang, Dipanjan Chowdhury, Gerd P Pfeifer, Yun Yen, XingZhi Xu. Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Research. 2008.18:974-977.
5. Dipanjan Chowdhury, Xingzhi Xu, Xueyan Zhong, Fariyal Ahmed, Jianing Zhong, Ji Liao, Derek M. Dykxhoorn, David M. Weinstock, Gerd P. Pfeifer, and Judy Lieberman. A PP4-Phosphatase Complex Dephosphorylates g-H2AX Generated during DNA Replication. Molecular Cell. 2008. 31, 1–14.
6. Puline Douglas, Jianing Zhong, Ruiqiong Ye, Greg B. G. Moorhead, Xingzhi Xu, and Susan P. Lees-Miller. 2010. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and dephosphorylates γ-H2AX. Molecular & Cellular Biology. 2010. 00741-09.
7. Jianing Zhong, Ji Liao, Wenya Hou, Jeremy M. Stark, Susan P. Lees-Miller, Xingzhi Xu .Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle. 2011. 10:9, 1-9.
8. Liu J, Xu L, Zhong J, Liao J, Li J, Xu X. Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks.Cell Cycle. 2012 Jul 15;11(14):2643-9
9. Jianbin Zhang, Xin Suna, Liming Wang, Yin Kwan Wong, Yew Mun Lee, Chao Zhoua,Guoqing Wu, Tongwei Zhao, Liu Yangb, Liqin Lu, Jianing Zhong, Dongsheng Huang,Jigang Wang. Artesunate-induced mitophagy alters cellular redox status.2018. Redox Biology. Aug 19 263–273 一区
10. Yue-Lei Chen, Yihe Zhang, Junwen Wang, Na Chen, Weiying Fang, Jianing Zhong, Yi Liu, Rui Qin, Xinxin Yu, Zhongsheng Sun*, Fei Gao*. A 17 gene panel for non-small-cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition. Molecular Oncology. 2019 Apr 11. doi: 10.1002/1878-0261.12491.二区
11. Bingxin Lu#, Jianing Zhong#, Jianfei Pan, Xiaopeng Yuan, Mingzhi Ren, Liping Jiang, Yuqing Yang, Guisheng Zhang, Dexi Liu, Chunbo Zhang. Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice. J Transl Med. 2019 Dec 17;17(1):422. 二区
12. Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Sci Adv. 2019 Jul 24;5(7):eaaw7935.一区
13. Yongwei Xiao, Lei Zheng, Xiaofeng Zou, Jigang Wang, Jianing Zhong & Tianyu Zhong. Extracellular vesicles in type 2 diabetes mellitus: key roles in pathogenesis, complications, and therapy. Journal of Extracellular Vesicles. 2019. Vol. 8, 1625677. 一区
14. Yongwei Xiao#, Jianing Zhong#, Baoyuan Zhong, Junyun Huang, Lixia Jiang, Yu Jiang, Jimin Yuan, Jichao Sun, Lingyun Dai, Chuanbin Yang, Zhijie Li, Jigang Wang, Tianyu Zhong. Exosomes as potential sources of biomarkers in colorectal cancer. Cancer letters. 2020. Apr 28;476:13-22. 一区
15. Zeming Hu, Fangfang Xie, Ang Hu, Mengjing Xu, Yuwen Liu, Jiankang Zhang, Jianbo Xiao, Yunlei Song, Jianing Zhong, Bin Chen. Silencing glioma-associated oncogene homolog 1 suppresses the migration and invasion of hepatocellular carcinoma in vitro. Oncol Lett. 2020 Nov;20(5):228.13.三区
16. Qinkai Zhang, Xunzhu Zhou, Maoping Wan, Xixi Zeng, Jiarong Luo, Yesha Xu, Liying Ji, Jian-An Zhang, Pei Fan, Jianing Zhong#, Jianmin Wu#. FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop. Cell Death Dis. 2021 Mar 15;12(3):275.二区
17. Tao Wang, Shasha Ruan, Xiaolu Zhao, Xiaohui Shi, Huajing Teng, Jianing Zhong, Mingcong You, Kun Xia, Zhongsheng Sun, Fengbiao Mao. OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers. Nucleic Acids Res. 2021 Jan 8;49(D1):D1289-D1301.一区
18. Defa Huang, Jie Chen, Die Hu, Fangfang Xie, Tong Yang, Zhengzhe Li, Xiaoxing Wang, Yongwei Xiao, Jianing Zhong, Yu Jiang, Xiaokang Zhang, Tianyu Zhong. Advances in Biological Function and Clinical Application of Small Extracellular Vesicle Membrane Proteins. Front Oncol. 2021 May 20;11:675940.二区
19. Die Hu, Fangfang Xie, Yongwei Xiao, Chen Lu, Jianing Zhong, Defa Huang, Jie Chen, Jifu Wei, Yu Jiang, Tianyu Zhong. Metformin: A Potential Candidate for Targeting Aging Mechanisms. Aging Dis. 2021 Apr 1;12(2):480-493. 二区
20. Jing Wu, Lin-Lin Liu, Miao Cao, Ang Hu, Die Hu, Yan Luo, Hui Wang, Jia-Ning Zhong. DNA methylation plays important roles in retinal development and diseases. Exp Eye Res. 2021 Oct;211:108733. 二区
21. Chunbo Zhang, Tianyu Zhong, Yuanyuan Li, Xianfeng Li, Xiaopeng Yuan, Linlin Liu, Weilin Wu, Jing Wu, Ye Wu, Rui Liang, Xinhua Xie, Chuanchuan Kang, Yuwen Liu, Zhonghong Lai, Jianbo Xiao, Zhixian Tang, Riqun Jin, Yan Wang, Yongwei Xiao, Jin Zhang, Jian Li, Qian Liu, Zhongsheng Sun, Jianing Zhong. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. Elife. 2021 Nov 5;10:e70672. 一区
7、科研成果及获奖情况
共发表SCI论文21篇。首次发现DNA去甲基化酶TET1能够调控H4K16位点乙酰化水平从而调控DNA损伤修复的机制。该研究提示TET1及其调控的组蛋白乙酰化修饰可能作为研究结肠癌治疗药物的靶蛋白。我们后续一系列工作将系统地研究和肿瘤、糖尿病相关的组蛋白修饰改变及其调控机制。
8、主要学术任职
江西省医学遗传学会理事
江西省细胞生物学会理事
9、联系方式（办公电话、邮箱、地址等）
办公室电话：0797-8169163
Email： zhongning_003@163.com
办公地址：赣南医学院黄金校区第五实验楼417房间
