
尹卫民,博士,讲师。2025年毕业于同济大学,获博士学位,同年入职赣南医科大学基础医学院。长期致力于纳米药物制剂领域的研究,聚焦抗实体瘤治疗中的重大瓶颈问题,围绕纳米制剂与免疫生物学的交叉前沿方向,系统探索肿瘤微环境调策略,并重点发展金属离子介导的抗肿瘤免疫治疗新途径。
科研成果:
截至目前,以第一作者(含共同第一作者)或通讯作者身份,在Advanced Composites and Hybrid Materials,Chemical Engineering Journal,Small,Biomaterials,Theranostics等SCI期刊上发表论文12篇,其中中科院一区期刊论文9篇,累计影响因子超过130。此外,受邀担任Signal Transduction and Targeted Therapy,Molecular Cancer,Small等国际权威期刊的特邀审稿人。
在研基金项目:
主持校级高层次人才启动基金1项,主持2026年国家自然科学基金地区基金项目1项,参与2026年国家自然科学基金地区基金项目1项。
研究方向:
(1) 肿瘤细胞通过代谢重编程形成对铜、铁离子的“代谢成瘾”,这一特征使其对两种死亡方式(铜死亡/铁死亡)表现出天然敏感性,也为靶向金属稳态的抗肿瘤策略提供了重要理论依据。本课题组组围绕如何高效诱导肿瘤细胞的铜死亡与铁死亡过程,开展了系统深入的研究工作。从金属离子递送策略的构建,到作用机制的深入解析,再到新型协同治疗策略的开发,形成了完整的研究体系。
(2) 探索纳米生物医学与炎症性疾病机制的深度交叉,旨在利用纳米材料的物理化学特性,调整病灶微环境,发展炎症治疗的新型干预策略。
代表作:
(1) Weimin Yin#, Yuge Zhao# et al. BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFRT790M mutation. Theranostics 2020.05; DOI: 10.7150/thno.42234; (IF = 14.9,中科院一区)
(2) Weimin Yin#, Jiao Chang# et al. Arginine nanoparticles mediated closed-loop ferroptosis enhancement for T cell activity boosting in cancer immunotherapy. Applied Materials Today 2023.12; DOI: 10.1016/j.apmt.2023.102047; (IF = 8.4,中科院二区
)(3) Weimin Yin#, Jiao Chang# et al. Copper deposited metal-phenolic networks enabled crosstalk between cuproptosis and ferroptosis for triple-negative breast cancer immunotherapy. Chemical Engineering Journal 2025.05; DOI: 10.1016/j.cej.2025.163577; (IF = 13.4,中科院一区)
(4) Jiao Chang#, Weimin Yin# et al. Copper depositition in polydopamine nanostructure to promote cuproptosis by catalytically inhibiting copper exporters of tumor cells for cancer immunotherapy. Small 2024.02; DOI: 10.1002/smll.202308565; (IF = 13.0,中科院二区)
(5) Hui Zhi#, Weimin Yin# et al. Lactate metabolism regulating nanosystem synergizes cuproptosis and ferroptosis to enhance cancer immunotherapy. Biomaterials 2025.07; DOI: 10.1016/j.biomaterials.2025.123538; (IF = 12.8,中科院一区)
(6) Weimin Yin #, Yang Li# et al. Hypoxia nanoalleviator with dual disruption of iron and redox metabolism for efficient ferroptosis-mediated cancer immunotherapy. Advanced Composites and Hybrid Materials 2026.04; DOI: 10.1007/s42114-026-01734-6; (IF = 15.4,中科院一区)
课题组地址:赣南医科大学蓉江校区第四实验楼
联系方式:Tel.: 17721247039(微信同号),E-mail: yinweimin_123@126.com